Lipoprotein(a)

What does high lipoprotein mean? It consists of a particle similar to LDL and protein molecules known as ApoB and Apo (a). Genetic and epidemiological studies have identified lipoprotein (a) as a risk factor for atherosclerosis and related diseases, such as coronary heart disease and stroke.

Overview Low-density lipoprotein (LDL), or “bad cholesterol,” is typically associated with an increased risk of heart attack and stroke. The lipoproteins vary in the major lipoprotein present and the relative contents of the different lipid components.

Lipoproteins are substances made up of protein and fat. Lp (a ) is a lipoprotein rich in cholesterol. It differs from LDL as it contains an additional protein, apolipoprotein (a). A lipoprotein (a ) test measures the level of lipoprotein (a ) in your blood. The amount your body makes is inherited from one or both parents and is determined by the genes passed on from your parent (s) when you are born.

Lp ( a ) is an important but underappreciated risk factor for heart disease. While most people know that low-density lipoprotein (LDL)-C, or bad cholesterol, can cause heart disease, relatively few people know about the risk posed by lipoprotein ( a ), or Lp ( a ).

They occur in both soluble complexes—as in egg yolk and mammalian blood plasma —and insoluble ones, as in cell membranes. The name of this glycoprotein is apolipoprotein (a). Elevated lipoprotein ( a ) is a genetic condition.

A healthcare provider cannot tell if a patient has elevated lipoprotein ( a ) by examining them. The LDL-like moiety is composed of a central core of cholesteryl esters (CE) and triglycerides (TG) surrounded by phospholipids (PL), free cholesterol (FC),. Apo( a ) contains a specific sequence, such as kringle IV, similar to plasminogen ( a fibrinolytic molecule) (3-5). And even though they play a critical role in our metabolism, LDL are not our friends when they become too numerous.

They also differ by population and may vary. It’s estimated that about one in five people in the U. Lp (a) level that puts them at risk. Note: Fill in one box to get in the other box by clicking Calculate button.

There are no approved pharmacologic therapies to lower. Data should be separated in coma (,), space ( ), tab, or in separated lines. Definition of lipoprotein : a conjugated protein that is a complex of protein and lipid — compare HDL, LDL, VLDL Examples of lipoprotein in a Sentence Recent Examples on the Web The drug inserted the gene for lipoprotein lipase into muscle cells.

The physiologic function of this lipoprotein ( a ) is unknown 13).

Unlike low-density lipoprotein , apo ( a ) levels are only modestly altered by diet, and it is likely that apo ( a ) impairs the uptake of Lp ( a ) via receptors that bind apoB. Lp( a ) is a subgroup or a sub-type of the cholesterol that is in the blood. The relationship between high Lp( a ) and arterial atherosclerosis and arterial thrombotic events is well established.

Such an association with venous thrombosis is less clear. However, the relationship between Lp ( a ) levels, PCSKinhibition, and cardiovascular risk reduction remains undefined. Phospholipids are molecules of fats which are attached to a. The assay method requires only μL of serum sample and is completed in less than minutes.

It’s also distinctive for having been dubbed one of the final frontiers in lipid management — and for good reason. In this trial, we found that APO ( a )-L Rx provided potent.